Eudaxen (Diazoxide): Generic Proglycem Alternative

Eudaxen is a WHO-GMP-manufactured generic tablet form of diazoxide, the active ingredient in the originator brand Proglycem. Made by Everest Pharmaceuticals in Bangladesh, it’s used to manage hypoglycemia (low blood sugar) caused by insulin-secreting tumors and other forms of hyperinsulinism, and it’s available through genericoncology.com’s Named Patient Program for patients in countries where Proglycem itself isn’t stocked.

What Is Eudaxen (Diazoxide)?

Eudaxen is Everest Pharmaceuticals’ brand of diazoxide, supplied as a 50 mg oral tablet under WHO-GMP manufacturing standards. Diazoxide is not a chemotherapy drug. It’s an antihypoglycemic agent: a compound that raises blood sugar rather than lowering it, the opposite of what its chemical relatives, thiazide diuretics, do.

People searching for a “Proglycem generic” are usually looking for a way to continue treatment when Proglycem is unavailable, back-ordered, or not distributed in their country. Eudaxen, which contains the same active ingredient, is the tablet genericoncology.com sources for that purpose under its Named Patient Program.

Eudaxen vs. Proglycem: What “Generic Alternative” Means Here

Proglycem is the original brand under which diazoxide was FDA-approved in the United States, first as 50 mg and 100 mg capsules. Those brand-name capsules are now discontinued in the US, and no generic capsule has replaced them. The only FDA-approved generic diazoxide product currently sold in the US is a 50 mg/mL oral suspension (liquid), made by E5 Pharma and by Novitium Pharma (distributed as Par Health USA).

Eudaxen fills a different gap. It’s a 50 mg solid tablet, manufactured separately by Everest Pharmaceuticals under WHO-GMP certification and approved for manufacture and sale under Bangladesh’s national drug regulatory framework, not by the FDA. It’s the option for patients or physicians who need a tablet rather than a liquid, or who are outside the US where the suspension generic isn’t distributed.

Both products contain the same active ingredient, diazoxide, but they’re different dosage forms, from different manufacturers, under different regulatory approvals. They aren’t interchangeable without a physician’s guidance.

For a small molecule like diazoxide, bioequivalence between the originator and a WHO-GMP generic is expected on pharmacological grounds, but genericoncology.com doesn’t publish a bioequivalence claim for Eudaxen specifically, because Everest Pharmaceuticals hasn’t supplied comparative dissolution or pharmacokinetic data for this product. Anyone switching between diazoxide products should do so under a physician’s supervision, with the monitoring described below.

WHO-GMP certification confirms that the manufacturing facility meets World Health Organization Good Manufacturing Practice standards. That’s a separate thing from FDA product approval, and this page makes no claim that Eudaxen itself is FDA-approved.

How Diazoxide Works

Diazoxide raises blood sugar. It works mainly by stopping the pancreas from releasing insulin, the hormone that normally lowers blood sugar, with a smaller additional effect elsewhere in the body that also pushes glucose up. After a dose, blood sugar typically starts rising within about an hour, and the effect lasts up to eight hours in someone with normal kidney function. That’s why the daily dose is usually split into two or three smaller doses rather than taken all at once.

Approved Uses

As a generic diazoxide product, Eudaxen is approved for the same clinical uses as the originator, Proglycem.

Oncology-relevant use (why this product is in genericoncology.com’s catalog): Diazoxide manages hypoglycemia caused by an insulin-producing pancreatic tumor (an inoperable islet cell adenoma or carcinoma) that can’t be surgically removed, or by certain other tumors outside the pancreas that produce an insulin-like effect. In practice, this covers insulinoma patients who aren’t surgical candidates, and cancer patients whose tumor is causing dangerously low blood sugar as a side effect (paraneoplastic hypoglycemia). Diazoxide manages the blood sugar; it does not treat the tumor itself.

Other approved uses (not cancer-related, included here for completeness): Diazoxide is also used for hypoglycemia caused by non-cancer conditions, mainly in infants and children with congenital hyperinsulinism, including leucine sensitivity, an overgrown pancreas (islet cell hyperplasia), nesidioblastosis, and islet cell adenomatosis. These are legitimate, labeled uses; they’re described here for accuracy rather than tagged as oncology uses, since they aren’t cancer-related.

Diazoxide is not a treatment for type 2 diabetes or for functional (reactive) hypoglycemia, and it does not lower blood sugar; it raises it.

Dosage and Administration

The dosing below reflects Everest Pharmaceuticals’ own published labeling for Eudaxen, since this is the product actually dispensed under this listing:

• Initial dose: approximately 5 mg per kg of body weight per day, in 2–3 divided doses.
• Maintenance dose: typically 3–8 mg per kg per day, in divided doses, adjusted by the prescribing physician based on blood sugar response.
• Leucine-sensitive hypoglycemia (a specific childhood form): 15–20 mg per kg per day.
• Insulin-secreting tumor cases: up to 1,000 mg per day in some patients, under close monitoring.

Always follow the exact dose and schedule on the package insert that ships with your specific Eudaxen pack, and the instructions given by your prescribing physician. Dosing is individualized and depends on body weight, the underlying cause of the hypoglycemia, and how blood sugar responds over time. Diazoxide is taken by mouth, with or without food.

(Note: other diazoxide labels internationally, including the original Proglycem prescribing information, use a different starting-dose convention. That’s a labeling difference between products, not a range to choose from. The label on the pack you’re dispensing, and your physician’s instructions, are what govern.)

Monitoring During Therapy

Because diazoxide affects blood sugar, kidney function, blood cells, and the heart, physicians typically monitor:

• Blood glucose, at regular intervals until it stabilizes
• Kidney function (blood urea nitrogen and creatinine clearance)
• Blood cell counts (hematocrit, platelets, and white blood cells)
• Liver enzyme levels (serum AST)
• Uric acid levels
• Urine tests for glucose and ketones

Diazoxide stays in the body longer than many drugs, so effects like diabetic ketoacidosis or a hyperosmolar coma (two serious high-blood-sugar emergencies) can develop days after starting or changing the dose, not just in the first 24 hours. Monitoring is generally continued for up to a week after any dose change.

Warnings and Precautions

Diazoxide affects more than blood sugar, and the points below matter for anyone taking it, especially at higher doses or over a longer course. Review this section with your physician before starting treatment.

• Fluid retention: Sodium and water retention (fluid buildup) are common, especially in infants and adults, and can trigger heart failure in patients whose heart function is already compromised. Diazoxide is used cautiously in these patients, sometimes alongside a diuretic.
• Diabetic ketoacidosis and hyperosmolar coma: These serious blood-sugar emergencies can develop quickly. Because diazoxide’s effects last for days, monitoring continues for up to a week after starting or changing the dose.
• Pulmonary hypertension (high blood pressure in the lungs): Reported in newborns and infants treated with diazoxide. Watch for signs of breathing difficulty in this age group.
• Effects with long-term use: Temporary clouding of the eye’s lens (cataracts) and changes in facial features have been reported with extended use.
• Pregnancy: Diazoxide caused birth defects in animal studies, and its safety in human pregnancy hasn’t been established.

Contraindications

• Functional hypoglycemia (low blood sugar not caused by an insulin-related medical condition)
• Known hypersensitivity to diazoxide, to thiazide drugs, or to other ingredients in the tablet

Side Effects

The most commonly reported effects are sodium and fluid retention (most common in young infants and adults); hirsutism (extra fine body hair, mainly in children and women); high blood sugar or sugar in the urine; and stomach-related effects such as loss of appetite, nausea, vomiting, stomach pain, and diarrhea. A faster heartbeat, palpitations, raised uric acid levels, and a drop in platelet count (which can affect blood clotting) have also been reported. The original Proglycem label doesn’t give exact percentages for how often each of these occurs, so they’re described here by how commonly they’re reported rather than with a specific number this page can’t source.

Drug Interactions

• Thiazide diuretics: May increase diazoxide’s blood-sugar-raising and uric-acid-raising effects.
• Phenytoin (an anti-seizure medicine): Taking it with diazoxide has been linked to loss of seizure control.
• Blood thinners such as coumarin-type anticoagulants: Diazoxide binds tightly to blood proteins and may displace these drugs, raising their effective level in the blood.
• Blood pressure medicines: Their blood-pressure-lowering effect may be stronger when combined with diazoxide.

Regulatory and Manufacturing Note

Eudaxen is manufactured by Everest Pharmaceuticals Ltd. at a WHO-GMP certified facility. That certification applies to the manufacturing site and its processes. It is not the same as FDA product approval, and shouldn’t be read as implying it. Proglycem’s FDA approval history belongs to the originator product, not to Eudaxen. genericoncology.com facilitates access to Eudaxen as a WHO-GMP generic under Named Patient Program frameworks, used where the originator product is unavailable, difficult to import in small quantities, or not registered locally.

Availability Through genericoncology.com

Patients looking into generic Proglycem availability outside markets where the originator is stocked can request Eudaxen through genericoncology.com’s Named Patient Program process:

1. Upload a valid prescription via the Upload Prescription page.
2. Our team confirms the order against the prescription and current Everest Pharmaceuticals stock.
3. Shipment is arranged under the import provisions that apply to your destination country.

Frequently Asked Questions